|
|
NADP+ + morphine <=> NADPH + morphinone + H+
|
1.1.1.218
morphine 6-dehydrogenase
1.1.1.247
codeinone reductase (NADPH)
|
–
–
|
MK
|
|
BRENDA:
BR29259
KEGG:
R03592
MetaCyc:
MORPHINE-6-DEHYDROGENASE-RXN
SABIO-RK:
3375
|
|
|
|
NAD+ + morphine <=> NADH + morphinone + H+
|
1.1.1.218
morphine 6-dehydrogenase
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
|
–
–
|
K
|
|
BRENDA:
BR29259-a
KEGG:
R03591
MetaCyc:
MORPHINE-6-DEHYDROGENASE-RXN_WOP
SABIO-RK:
3374
|
|
|
|
codeine + 2-oxoglutarate + O2 <=> morphine + formaldehyde + succinate + CO2
|
1.14.11.32
codeine 3-O-demethylase
|
–
|
MK
|
|
BRENDA:
BR49146
KEGG:
R09402
MetaCyc:
RXN-8152
|
|
|
|
UDP-glucuronate + morphine <=> UDP + morphine_3-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
K
|
|
BRENDA:
BS375362;
BS456010
KEGG:
R08262
SABIO-RK:
9918
|
|
|
|
UDP-glucuronate + morphine <=> UDP + morphine_6-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
K
|
|
BRENDA:
BS378148
KEGG:
R08263
SABIO-RK:
11754
|
|
|
|
morphine + flavin + formaldehyde + H2O <=> codeine + reduced_flavodoxin + O2
|
1.14.14.1
unspecific monooxygenase
|
–
|
K
|
|
KEGG:
R03697
|
|
|
|
morphine + reduced_flavodoxin + O2 <=> normorphine + formaldehyde + flavin + H2O
|
1.14.14.1
unspecific monooxygenase
|
–
|
K
|
|
KEGG:
R08265
|
|
|
|
morphine + UDP-glucuronate <=> UDP + morphine_3,6-diglucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
|
BRENDA:
BS322172
|
|
|
|
morphine + UDP-glucuronate <=> UDP + morphine_3-O-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
|
BRENDA:
BS456008
|
|
|
|
morphine + UDP-glucuronate <=> UDP + morphine_beta-D-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
|
BRENDA:
BS456009
|
|
|
|
UDP-glucuronate + morphine <=> UDP + morphine_beta-D-glucuronoside
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
|
BRENDA:
BS456880
|
|
|
|
morphine + UDP-glucuronate <=> UDP + morphine_3-glucuronide + morphine_6-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
|
BRENDA:
BS389182
|
|
|
|
6-monoacetylmorphine + H2O <=> morphine + acetate
|
3.1.1.1
carboxylesterase
3.1.1.6
acetylesterase
3.1.1.7
acetylcholinesterase
3.1.1.8
cholinesterase
3.1.1.84
cocaine esterase
|
–
–
–
–
–
|
|
|
BRENDA:
BS115471
|
|
|
|
3,6-diacetylmorphine + H2O <=> morphine + acetate
|
3.1.1.6
acetylesterase
|
–
|
|
|
BRENDA:
BS364355
|
|
|
|
ATP + H2O + morphine <=> ADP + phosphate + morphine
|
7.6.2.2
ABC-type xenobiotic transporter
|
–
|
|
|
BRENDA:
BS445085
|
|